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KMID : 0613820110210040589
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Journal of Life Science
2011 Volume.21 No. 4 p.589 ~ p.595
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In vitro Antimicrobial Activity of a New Isolate Streptomyces sp. BCNU 1030
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Bang Ji-Hun
Choi Hye-Jung
Ahn Cheol-Soo
Kim Dong-Wan
Jeong Young-Kee
Joo Woo-Hong
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Abstract
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This work focused on screening and characterizing antibiotic-producing actinomycetes to develop new antibiotics that can overcome the growing resistance of disease-causing microbes. One-hundred actinomycetes strains were isolated from soil samples from Chungcheongbuk-do, Korea using various kinds of actinomycetes isolation media, including a starch casein agar medium and potato dextrose agar (PDA). Among them, strain BCNU 1030 was determined to show strong antimicrobial activity against methicillin-resistant Staphylococcus aureus(MRSA). Biochemical, physiological, and 16S rRNA sequence analyses indicated that strain BCNU 1030 belonged to the genus Streptomyces. Strain BCNU 1030 exhibited antibiotic activity against a wide range of bacteria, especially methicillin-resistant Staphylococcus aureus(MRSA). The minimum inhibitory concentration (MIC) of BCNU 1030 dichloromethane extract was determined to be 0.78 ㎍/㎖ for MRSA CCARM 3090 .Therefore, Streptomycessp. BCNU 1030 has potential for anti-MRSA drug development.
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KEYWORD
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Antibacterial activity, methicillin-resistant Staphylococcus aureus, minimum inhibitory concentration, Streptomyces
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